Vitamin D Receptor (VDR) Regulation of Voltage-Gated Chloride Channels by Ligands Preferring a VDR-Alternative Pocket (VDR-AP)
نویسندگان
چکیده
منابع مشابه
Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin
The vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily. The VDR binds to active vitamin D3 metabolites, which stimulates downstream transduction signaling involved in various physiological activities such as calcium homeostasis, bone mineralization, and cell differentiation. Quercetin is a widely distributed flavonoidin nature that is known to enhance transactivation ...
متن کاملDifferential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage.
p63 and p73, members of the p53 family, have been shown to be functionally distinct from p53. Vitamin D receptor (VDR) is a ligand (vitamin D(3))-dependent transcription factor, which is shown to play a major role in calcium homeostasis and keratinocyte differentiation. Vitamin D and its analogues in combination with DNA-damaging agents are extensively used for cancer chemotherapy. In this repo...
متن کاملAnalysis of Vitamin D Receptor (VDR) Gene Polymorphisms in Alopecia Areata Alopesi Areata’da Vitamin D Reseptör (VDR) Polimorfizminin Analizi
DOI: 10.4328/JCAM.4795 Received: 31.08.2016 Accepted: 14.09.2016 Printed: 01.03.2017 J Clin Anal Med 2017;8(2): 151-4 Corresponding Author: Ömer Ateş, Department of Medical Biology, Gaziosmanpasa University, Medical Faculty, 60100, Tokat, Turkey. GSM: +905327119955 E-Mail: [email protected] Özet Amaç: Alopesi areata (AA), vücudun herhangi bir bölgesindeki saçlı deride meydana gelen saç kaybı...
متن کاملVDR and gemini ligands.
The active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1,25(OH) 2 D 3 ; calcitriol], plays a key role in mineral and bone homeostasis, and exerts potent anti-inflammatory and anti-proliferative activities [1]. It is thus a potential pharmacological agent to treat various diseases, including autoimmune disorders, infections and cancer [1]. However, the 1,25(OH) 2 D 3 doses required to elicit s...
متن کاملVitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians.
Associations have been reported between vitamin D receptor (VDR) gene polymorphisms, type 1 diabetes, insulin secretion, and the insulin resistance syndrome. As VDR polymorphisms have no known functional significance, these findings may implicate a variant of the VDR gene or a locus in linkage disequilibrium with the VDR. We have examined VDR mRNA and VDR protein levels in relation to VDR polym...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2011
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2010-0442